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KMID : 0361020000430060604
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 6 p.604 ~ p.606
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Expression of MMP-9 and TIMP-1 in the Nasal Mucosa of Allergic Rhinitis
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이흥만/Heung han Lee
최진호/최충식/황순재/이상학/Jin Ho Choi/Choong Sik Choi/Soon Jae Hwang/Sang Hag Lee
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Abstract
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-Abstract-
Background and Objectives : Allergic rhinitis is characterized by airway structural changes, including
inflammation and basement thickening. An imbalance between matrix metalloproteinases(MMPs) and their
tissue inhibitors(TIMPs) is thought to play a critical role in the synthesis or degradation of the
extracellular matrix of the airway architecture. To elucidate the mechanism of remodeling in allergic
rhinitis, we investigated the expressions of MMP-9 and TIMP-1 in the nasal mucosa of allergic rhinitis
patients and the control subjects. We also compared the number infiltrating inflammatory cells
(eosinophils) and the immunostained areas of MMP-9 and TIMP-1. Materials and Methods : Nasal biopsy
specimens were obtained from 20 subjects with allergic rhinitis and 20 healthy control subjects, and the
extent of staining by MMP-9 and TIMP-1 was estimated by using immunohistochemical staining. Using
a computer assisted image analysis system, we quantified the expressions of MMP-9 and TIMP-1, and
number of inflammatory cells was also determined. Results : Expressions of MMP-9 and TIMP-1 were
observed in the nasal mucosa of epithelial cells and infiltrating inflammatory cells. The extent
immunostained ares of MMP-9 was significantly greater than that of TIMP-1 in the allergic rhinitis
patients. A significant correlation was found between the number of eosinophils and the extent of MMP-9
secreted from the infiltrating inflammatory cells and the nasal epithelium causes tissue remodeling in the
allergic nasal mucosa.
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